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In particular, it has been shown that T cell senescence can be characterized by some loss of both innate and adaptive immunity and a depletion of both nave and effector T cells 95,96

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The predicted translation products were aligned using the R package Biostrings v2.52.0, with BLOSUM100 as the score matrix, and alternative aa sequences were defined by comparing the predicted aa sequence of each mRNA isoform with that of the reference (canonical) mRNA, taking as reference the longest and/or most prevalent mRNA isoform in islets (alternative sequence generation filter)